朱守非-南开大学化学学院

来自 : chem.nankai.edu.cn/info/1029/6 发布时间：2021-03-24

朱守非长期从事催化有机合成化学研究，重点研究了几类以氢转移为关键步骤的重要有机合成反应，主要取得以下成果：
1）在质子转移反应方面，提出了“手性质子梭催化剂”概念，为不对称质子转移反应提供了全新的解决方案，实现了多种极具挑战的重要不对称催化合成反应，为α-氨基酸等重要手性砌块提供了高效合成方法，被称为“充满希望的未来研究领域”，为国内外多个课题组所采用，并引发了系列相关理论研究。
2）在氢原子转反应方面，发展了底物活化策略，通过加入Lewis碱提高了硼烷氢原子转移能力，实现了首例催化卡宾对硼氢键的插入反应，并实现了其不对称转化，被认为是“合成手性有机硼砌块的具有吸引力的方法，很可能广泛应用”，并已经引发多个课题组的跟进研究。
3）在负氢转移方面，发展了多种不对称氢化反应的高效催化剂，实现了多种重要羧酸类非甾体消炎药和生物碱的高效合成，部分成果已经被制药公司采用。
截至2017年11月发表SCI论文86篇，其中以通讯作者和第一作者在IF 10的化学顶级学术期刊上发表论文18篇（包括Nature Chemistry 1篇; Acc. Chem. Res. 2篇; JACS 9篇; ACIE 6篇；其中通讯作者论文11篇，第一作者论文7篇）；编写著作章节2篇（分别于2011年和2016年由Wiley-VCH出版）；获授权5项中国专利，申请3项国际专利；论文被他人正面引用3700余次，H-index为36。
代表作：
1. Shou-Fei Zhu*, Qi-Lin Zhou*, Iridium-catalyzed asymmetric hydrogenation of unsaturated carboxylic acids, Acc. Chem. Res. 2017, 50, 988-1001.
2. Huan Xu, Yi-Pan Li, Yan Cai, Guo-Peng Wang, Shou-Fei Zhu*, Qi-Lin Zhou*, Highly enantioselective copper- and iron-catalyzed intramolecular cyclopropanation of indoles, J. Am. Chem. Soc. 2017, 139, 7697-7700.
3. Ji-Min Yang, Zi-Qi Li, Mao-Lin Li, Qiao He, Shou-Fei Zhu*, Qi-Lin Zhou*, Catalytic B-H bond insertion reactions using alkynes as carbene precursors, J. Am. Chem. Soc. 2017, 139, 3784-3789.
4. Mao-Lin Li, Shuang Yang, Xun-Cheng Su, Hui-Ling Wu, Liang-Liang Yang, Shou-Fei Zhu*, Qi-Lin Zhou*, Mechanism studies of Ir-catalyzed asymmetric hydrogenation of unsaturated carboxylic acids, J. Am. Chem. Soc. 2017, 139, 541-547.
5. Guo-Peng Wang, Meng-Qing Chen, Shou-Fei Zhu*, Qi-Lin Zhou*, Enantioselective Nazarov cyclization of indole enones cooperatively catalyzed by Lewis acids and chiral Bronsted acids, Chem. Sci. 2017, 8, 7197-7202.
6. Shuang Yang, Wen Che, Hui-Ling Wu, Shou-Fei Zhu*, Qi-Lin Zhou*, Neutral iridium catalysts with chiral phosphine-carboxy ligands for asymmetric hydrogenation of unsaturated carboxylic acids, Chem. Sci. 2017, 8, 1977-1980.
7. Jun-Xia Guo, Ting Zhou, Bin Xu, Shou-Fei Zhu*, Qi-Lin Zhou, Enantioselective synthesis of α-alkenyl α-amino acids via N–H insertion reactions, Chem. Sci. 2016, 7, 1104-1108.
8. Bin Xu, Mao-Lin Li, Xiao-Dong Zuo, Shou-Fei Zhu*, Qi-Lin Zhou, Catalytic asymmetric arylation of α-aryl-α-diazoacetates with aniline derivatives, J. Am. Chem. Soc. 2015, 137, 8700-8703.
9. Cui Guo, Dong-Wei Sun, Shuang Yang, Shen-Jie Mao, Xiao-Hua Xu*, Shou-Fei Zhu*, Qi-Lin Zhou*, Iridium-catalyzed asymmetric hydrogenation of 2-pyridyl cyclic imines: a highly enantioselective approach to nicotine derivatives, J. Am. Chem. Soc. 2015, 137, 90-93.
10. Jun-Jie Shen, Shou-Fei Zhu*, Yan Cai, Huan Xu, Xiu-Lan Xie, Qi-Lin Zhou, Enantioselective iron-catalyzed intramolecular cyclopropanation reactions, Angew. Chem. Int. Ed. 2014, 53, 13188-13191.
11. Bin Xu, Shou-Fei Zhu*, Xiao-Dong Zuo, Zhi-Chao Zhang, Qi-Lin Zhou*, Enantioselective N?H insertion reaction of α-aryl α-diazoketones: an efficient access to chiral α-aminoketones, Angew. Chem. Int. Ed. 2014, 53, 3913-3916.
12. Xiu-Lan Xie, Shou-Fei Zhu*, Jun-Xia Guo, Yan Cai, Qi-Lin Zhou*, Enantioselective palladium-catalyzed insertion of α-aryl-α-dizaoesters into the O-H bonds of phenols, Angew. Chem. Int. Ed. 2014, 53, 2978-2981.
13. Bin Xu, Shou-Fei Zhu*, Zhi-Chao Zhang, Zhi-Xiang Yu*, Yi Ma, Qi-Lin Zhou*, Highly enantioselective S?H bond insertion cooperatively catalyzed by dirhodium complexes and chiral spiro phosphoric acids, Chem. Sci. 2014, 5, 1442-1448.
14. Qing-Qing Cheng, Shou-Fei Zhu*, Yong-Zhen Zhang, Xiu-Lan Xie, Qi-Lin Zhou*, Copper-catalyzed B–H bond insertion reaction: a highly efficient and enantioselective C–B bond-forming reaction with amine-borane and phosphine-borane adducts, J. Am. Chem. Soc. 2013, 135, 14094-14097.
15. Bin Xu, Shou-Fei Zhu*, Xiu-Lan Xie, Jun-Jie Shen, Qi-Lin Zhou*, Asymmetric N–H insertion reaction cooperatively catalyzed by rhodium and chiral spiro phosphoric acids, Angew. Chem. Int. Ed. 2011, 50, 11483-11486.