苏循成-南开大学化学学院

来自 : chem.nankai.edu.cn/info/1034/9 发布时间：2021-03-24

科研成果与代表作已发表论文50余篇，其中包括Immunity, Acc. Chem. Res., Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Angew. Chem., Nucl. Acids Res., J. Biol. Chem., J. Mol. Biol. 和 PLoS Neg.l Trop Dis. 等国际期刊. H-index 28.
近年来在生物顺磁共振方法发展，细胞原位条件下蛋白质动态特性分析等方面取得了重大研究突破：发展了通用的蛋白质顺磁标记策略和一系列顺磁探针(JACS 2008a; JACS 2008b; JACS 2009; JACS 2013; Angew Chem 2017)，并提出了顺磁探针柔性评价、质量评估体系 (J Biolmol NMR 2010; PCCP 2016；Chem Eur J 2013, 2017)；建立了低含量、不稳定酶催化中间体三维结构的顺磁核磁共振测定方法(Angew Chem 2016)；建立和发展了顺磁标记PCS快速测定活细胞内蛋白质三维结构方法(Chem Commun 2016)；联合 NMR和EPR研究细胞内蛋白质的动态结构测定方法(PhyChemChemPhy 2015, 2017; Angew Chem 2017)；并成功利用顺磁核磁揭示了钙离子通道MCU的离子传输机制(PNAS 2017)，以及STIM1与钙调素在膜融合过程中的蛋白互作过程(Nat Commun 2017)等。
1. Li X., Wu G., Yang Y., Fu S., Liu X., Kang H., Yang X.*, Su X. C.*, Shen Y*. Calmodulin dissociates the STIM1-Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8: 1042.
2. Gao J, Liang E, Ma R, Li F, Liu Y, Liu J, Jiang L, Li C, Dai H, Wu J, Su X. C., He W*, Ruan K*. Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange. Angew. Chem. Int. Ed. Engl. 2017, 56, 12982-12986.
3. Yang Y., Gong Y. J., Litinov A., Liu H. K., Yang F., Su X. C.*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944-26956.
4. Cao C, Wang S, Cui T, Su X. C.*, Chou J*. Ion and inhibitor binding of the double-ring ion selectivity filter of the Mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. USA, 2017, 114, E2846-E2851.
5. Yang Y, Yang F, Gong Y. J., Chen J. l., Goldfarb D.*, Su X. C.*. A reactive, rigid Gd(III) labelling tag for in-cell EPR distance measurements in proteins. Angew. Chem. Int. Ed. Engl. 2017, 56, 2914-2918.
6. Ma FH, Wang X, Chen JL, Wen X, Sun H*, Su XC*. Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects. Chem. Eur. J. 2017, 23, 926-934.
7. Li ML, Yang S, Su XC, Wu HL, Yang LL, Zhu SF, Zhou QL*. Mechanism Studies of Ir-Catalyzed Asymmetric Hydrogenation of Unsaturated Carboxylic Acids. J. Am. Chem. Soc. 2017, 139, 541-547.
8. Chen JL, Wang X, Yang F, Cao C, Otting G, Su XC*. 3D Structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 2016, 55, 13744-13748.
9. Yang F, Wang X, Pan BB, Su XC*. Single-armed phenylsulfonated pyridine derivative of DOTA is rigid and stable paramagnetic tag in protein analysis. Chem. Commun. 2016, 52, 11535-11538.
10. Pan B. B., Yang F. Ye Y., Wang J. T., Li C.*, Huber T.*, Su XC*. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Chem. Commun. 2016, 52, 10237-10240.
11. Ma RS, Li QF, Wang AD, Zhang JH, Liu ZJ, Wu JH, Su XC*, Ruan K*. Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer. Phys. Chem. Chem. Phys. 2016, 18, 13794-13798.
12. Yang Y, Huang F, Huber T, Su XC*. Site-specific tagging proteins with a rigid, small and stable transition metal chelator, 8-hydroxyquinoline, for paramagnetic NMR analysis. J. Biolmol. NMR 2016, 64, 102-113.
13. Chen JL, Yang Y, Zhang LL, Liang H, Huber T*, Su XC*, Otting G*. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. 2016, 18, 5850-5859.
14. Martorana A, Yang Y, Zhao Y, Li QF, Su XC*, Goldfarb D*. Mn(II) tags for DEER distance measurements in proteins via C-S attachment. Dalton 2015, 44, 20812-20816.
15. Yang Y, Wang JT, Pei YY, Su XC*. Site-specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic analysis. Chem. Commun. 2015, 51, 2824-2827.
16. Wang Z, Yang X, Guo S, Yang Y, Su XC, Shen Y, Long J. Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J. Biol. Chem. 2014, 289, 27376-27385.
17. Cao C, Chen JL, Yang Y, Huang F, Otting G, Su XC*. Selective 15N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR. 2014, 59, 251-261.
18. Ma FH, Chen JL, Li QF, Su XC*. Kinetic assay of Michael addition like thiol-ene reaction and the insight into protein bioconjugation. Chem. Asian J. 2014, 9, 1808-1816.
19. Yang Y, Chen JL, Su XC*. PCS in structural biology. Chin. J. Magn. Reson. (杨茵，陈家良，苏循成*. 蛋白质顺磁标记技术与生物核磁共振中的赝接触位移，波谱学杂志) 2014, 31, 155-171.
20. Su XC, Wang Y, Yagi H, Shishmarev D, Mason CE, Smith PJ, Vandevenne M, Dixon NE, Otting G*. Bound or free: interaction of the C-terminal domain of Escherichia coli single-stranded DNA-binding protein (SSB) with the tetrameric core of SSB. Biochemistry 2014, 52, 1925-1934.
21. Shishmarev D, Wang Y, Mason CE, Su XC, Oakley AJ, Graham B, Huber T, Dixon NE, Otting G*. Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy. Nucleic Acids Res. 2014, 42, 2750-2757.
22. Huang F, Pei YY, Zuo HH, Chen JL, Su XC*. Bioconjugation of proteins with a paramagnetic NMR and fluorescent tag. Chem. Eur. J. 2013, 19, 17141-17149.
23. Wei Z, Yang Y, Li QF, Huang F, Zuo HH, Su XC*. Noncovalent tagging proteins with paramagnetic lanthanide complexes for protein study. Chem. Eur. J. 2013, 19, 5758-5764.
24. Yang Y, Li QF, Cao C, Huang F, Su XC*. Site-specific labeling of proteins with a chemically stable, high-affinity tag for protein study. Chem. Eur. J. 2013, 19, 1097-1013.
25. Li J, Pilla KB, Li QF, Zhang Z, Su XC, Huber T, Yang J*. Magic angle spinning NMR structure determination of proteins from pseudocontact shifts. J. Am. Chem. Soc. 2013, 135, 8294-8303.
26. Zhou JY, Wan XJ, Liu YS, Zuo Y, Li Z, He GR, Long GK, Ni W, Li CS, Su XC, Chen YS*. Small molecules based on benzo[1,2-b:4,5-b \']dithiophene unit for high-performance solution-processed organic solar cells. J. Am. Chem. Soc. 2012, 134, 16345-16351.
27. Li QF, Yang Y, Maleckis A, Otting G*, Su XC*. Thiol-ene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR. Chem. Commun. 2012, 48, 2704-2706.
28. Su XC, Loh C-T, Ru Q, Otting G*. Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enzymes for selective 15N-labelling and production of perduterated proteins in H2O. J. Biomol. NMR 2011, 50, 35-42.